ITTC Project


Computational Prediction of Beta-Sheet Arrangement (K-INBRE)

Project Award Date: 07-01-2005



Description

It is widely believed that protein misfolding into beta aggregates or fibrils is a significant contributor to the onset of Alzheimers, Parkinsons, and other neurodegenerative diseases. Although knowledge of the mechanism for conformational change may be critical to control of these diseases, considerable uncertainty exists about the nature of aggregate formation and the nature of the fibrils. Computational prediction of the transformation may present a plausible approach to resolving some of the uncertainties. Use of long-range interactions in prediction of ?-strand arrangement in the formation of ?-sheets may well be an essential step to forecasting/determining the 3-D structure of proteins from amino acid sequences. Thus, a better understanding of ?-strand arrangement in ?-sheets will not only provide possible solutions to prevent intermolecular ?-sheet formation associated with neurodegenerative diseases but may also contribute to the success of 3-D structure prediction.


Investigators

Faculty Investigator(s): Jianwen Fang (PI)


Project Sponsors


Primary Sponsor(s): University of Kansas Medical Center Research Institute, Inc. (KUMCRI)


Partner with ITTC

The Information and Telecommunication Technology Center at the University of Kansas has developed several assistance policies that enhance interactions between the Center and local, Kansas, or national companies. 

ITTC assistance includes initial free consulting (normally one to five hours). If additional support is needed, ITTC will offer one of the following approaches: 

Sponsored Research Agreement

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Licensing and Royalty/Equity Agreement

An ITTC goal is the development of investment-grade technologies for transfer to, and marketing by, local, Kansas, and national businesses. To enhance this process, the Center has developed flexible policies that allow for licensing, royalty, and equity arrangements to meet both the needs of ITTC and the company.

Commercialization Development

Companies with a technology need that can be satisfied with ITTC's resources can look to us for assistance. We can develop a relationship with interested partners that will provide for the development of a technology suited for commercialization.

ITTC Resource Access

ITTC resources, including computers and software systems, may be made available to Kansas companies in accordance with the Center's mission and applicable Regents and University policies.

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